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The Commissioner of Patents and Trademarks Has received an application for a patent for a new and useful invention. The title and descrip- tion of the invention are enclosed. The require- ments of law have been complied with, and it has been determined that a patent on the in- vention shall be granted under the law. Therefore, this United States Patent Grants to theperson(s) having title to this patent the right to exclude others from making, using, offering for sale, or selling the invention throughout the United States of America or im- porting the invention into the United States of America for the term set forth below, subject to the payment of maintenance fees as provided by law. If this application was filed prior to June 8, 1995, the term of this patent is the longer of seventeen years from the date of grant of this patent or twenty years from the earliest effec- tive U.S. filing date of the application, subject to any statutory extension. If this application was filed on or after June 8, 1995, the term of this patent is twenty years from the U.S. filing date, subject to any statutory ex- tension. If the application contains a specific reference to an earlier filed application or ap- plications under 35 U.S.C. 120, 121 or365(c), the term of the patent is twenty years from the date on which the earliest application was filed, subject to any statutory extension.

United States Patent [19]

Jian et aL

US005911993A

[11] Patent Number: 5,911,993

[45] Date of Patent: June 15,1999

[54] HOMEOPATHIC ANTIDIABETIC TREATMENT

[76] Inventors: Ding Jian; Ding Qing. both of Room 404. Building 108. Chengzeyuan. Beijing University. Beijing. China

[21] Appl. No.: 08/966,650

[22] Filed: Nov. 10, 1997

[30] Foreign Application Priority Data Jan. 23. 1997 FONI China 97 I 002S5

[51] Int. 1.6 ........................... A61K 35/00; A61K 35/78

[52] U.S. CI. ......................................... 424/195.1; 514/866

[58] Field of Search .......................... 424/195.1; 514/866

[56] References Cited FOREIGN PATENT DOCUMENTS 3-106819 5-178749 s 17X7.10 A" 5/1991 7/1993 7/1 OQt Japan Japan Japan OTHER PI TBLIf 'ATTONS Men. "Studies on the Constituents of Sedum Alfredi". J. Taiwan Pharm Ass. 38 (1) pp. 52-66. 1986. Boissya et al. "Some Folklore Claims from the Brahmaputra Valley". Ethnomedidne 6 pp. 139-145. 1980. Chou. "Chrysoeriol 7-O-RhaJiinoside from Sedum Formo- sanum". Phytochemistry 15 p. 1420. 1976. PrimaryExaminerCarlos A. Azpiiru Assistant ExaminerBrian K. Seidleck Attorney, Agent, or FirmNixon & Vanderhye P.C.

[57] ABSTRACT A highly effective pure. natural, ingestible antidiabetic may be made from Shilianhua (Echevaria glauca, Sinocrassula berger, Crassulaceae) by washing leaves and/or stems of the Shilianhua plant, crushing them in a grinder, breaking the cell walls to form a filterable material, filtering the material to produce a filtrate, and decompressing and concentrating the filtrate to produce a concentrated solution. The cell walls may be broken using medical alcohol, quick freezing and thawing, or ultrasonic mixing. The concentrated solution is then made into a powder, or concentrated powder, by baking, crushing, and passage through a 60 mesh screen: using a silica gel column; using a Saphadex column; or by treatment with a CH,COOC,H, solution. Treatment of. or to prevent, diabetes by lowering blood sugar at least 10% (e.g. about 50%) is practiced by daily administration of about 50-100 mg of powdered extract of Echevaria glauca, Sinocrassula berger, Crassulaceae. or about 20-40 mg of concentrated powdered extract of Echevaria glauca, Sinocrassula berger, Crassulaceae.

11 Claims, 2 Drawing Sheets



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